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PrismRA Molecular Signature Test

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When PrismRA can help guide treatment decisions: intended use & case study examples

by Stu Steene-Connelly | Jul 3, 2024 | Patient Empowerment

When PrismRA can help guide treatment decisions: intended use & case study examples For patients with rheumatoid arthritis (RA), ineffective early treatment increases the likelihood of surgery, irreversible joint damage, and chronic pain.1 Prior to PrismRA,...

Examining the Clinical Utility of PrismRA

by Stu Steene-Connelly | May 15, 2024 | Patient Empowerment, Science & Technology

Examining the Clinical Utility of PrismRA PrismRA® is a blood-based precision medicine test used by over 1,400 advanced practitioners around the country to guide the treatment selection in their patients with rheumatoid arthritis. While validated precision medicine...
PrismRA Molecular Signature Test

PrismRA is a molecular signature response classifier (MSRC) that uses gene expression features, clinical features and anti-cyclic citrullinated protein (anti-CCP) antibody to detect a signature of non-response to tumor necrosis factor-α inhibitors (TNFi) for patients with rheumatoid arthritis. PrismRA predicts the patient’s likelihood of inadequately responding to all TNFi therapies. Response is defined as achieving ACR50 at 6 months. The PrismRA result is reported on a continuous 1 to 25 scale. The higher the score, the more likely the patient will have an inadequate response to TNFi therapies; the lower the score, the less likely the patient will have an inadequate response to TNFi therapies. However, a low score does not ensure a positive response to TNFi therapies.

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